Conemaugh Health System is the largest health care provider in west central Pennsylvania, with hospitals, physician offices, and outpatient centers in five counties. The parent company, Duke LifePoint Healthcare (NASDAQ:LPNT), owns and operates community hospitals, regional health systems, physician practices, outpatient centers, and post-acute facilities in growing regions, rural communities and small towns. It was set up in 1997 and headquartered in Brentwood, Tennessee. For the year ended December 31, 2015, consolidated revenues were $5.2 billion, an increase of 16.3% from the prior year. Conemaugh Health System is headquartered in Johnstown and employs over 4,500 people.

The Greater Johnstown Regional Technology Park is a recent $22.5 million redevelopment of the former Sani-Dairy site. The Tech Park involved private funding by Conemaugh Health System as well as several local, state and federal grants and loans to complete. Located in a state-designated Keystone Innovation Zone, the complex is a hub for sharing research and development in the information technology, health science and biotechnology fields, interacting with local universities, including the University of Pittsburgh at Johnstown.

Founded in 1927, the University of Pittsburgh – Johnstown is the first and largest regional campus of the University of Pittsburgh, situated on 655 picturesque acres. Current enrollment is estimated at 3,000 students with an additional 500 staff and faculty members. University of Pittsburgh – Johnstown offers its students access to 48 undergraduate majors, 100 student organizations, and 15 NCAA Division II athletic teams.